Assay Detail
Binding
CHEMBL1071576
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Inhibition of wild-type JNK2 by isothermal calorimetry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.22 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611079 | — | — | 1 | 5.55 |
| CHEMBL508280 | — | — | 1 | 5.09 |
| CHEMBL609039 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611079 | — | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL508280 | — | Kd | = | 8100.0 | nM | 5.09 |
| CHEMBL609039 | — | Kd | = | 9400.0 | nM | 5.03 |