Assay Detail
Functional
CHEMBL1071779
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Antiinflammatory activity in rat PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.79 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186113 | GW-328267 | 1.0 | 1 | 8.54 |
| CHEMBL331372 | CGS-21680 | — | 1 | 7.08 |
| CHEMBL464859 | NECA | — | 1 | 6.73 |
| CHEMBL592541 | — | — | 1 | 6.59 |
| CHEMBL592540 | — | — | 1 | 6.34 |
| CHEMBL604591 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186113 | GW-328267 | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL331372 | CGS-21680 | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL464859 | NECA | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL592541 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL592540 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL604591 | — | IC50 | = | 3591.0 | nM | 5.45 |