Assay Detail
Binding
CHEMBL1072267
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Inhibition of rat kidney aldehyde reductase at 0.1 mM after 20 mins by spectrometric analysis
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL3871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 8 | - | - |
| IC50 | 1 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | 4.30 |
| CHEMBL602309 | — | — | 1 | - |
| CHEMBL590016 | — | — | 1 | - |
| CHEMBL592208 | — | — | 1 | - |
| CHEMBL589792 | — | — | 1 | - |
| CHEMBL590017 | — | — | 1 | - |
| CHEMBL590230 | — | — | 1 | - |
| CHEMBL602310 | — | — | 1 | - |
| CHEMBL93723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109 | VALPROIC ACID | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL602309 | — | Inhibition | = | 20.0 | % | - |
| CHEMBL590016 | — | Inhibition | = | 22.0 | % | - |
| CHEMBL592208 | — | Inhibition | = | 23.0 | % | - |
| CHEMBL589792 | — | Inhibition | = | 41.0 | % | - |
| CHEMBL590017 | — | Inhibition | = | 35.0 | % | - |
| CHEMBL590230 | — | Inhibition | = | 18.0 | % | - |
| CHEMBL602310 | — | Inhibition | = | 18.0 | % | - |
| CHEMBL93723 | — | Inhibition | = | 34.0 | % | - |