Assay Detail
Binding
CHEMBL1072437
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Inhibition of Mycobacterium avium DHFR at 37 degC by spectrophotometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.41 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.82 |
| CHEMBL596672 | — | — | 1 | 8.01 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.52 |
| CHEMBL598293 | — | — | 1 | 4.79 |
| CHEMBL611984 | — | — | 1 | 4.63 |
| CHEMBL598090 | — | — | 1 | 4.62 |
| CHEMBL597885 | — | — | 1 | 4.59 |
| CHEMBL598292 | — | — | 1 | 4.55 |
| CHEMBL604722 | — | — | 1 | 4.51 |
| CHEMBL596680 | — | — | 1 | 4.25 |
| CHEMBL596681 | — | — | 1 | 4.21 |
| CHEMBL609896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL596672 | — | IC50 | = | 9.73 | nM | 8.01 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL598293 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL611984 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL598090 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL597885 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL598292 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL604722 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL596680 | — | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL596681 | — | IC50 | = | 61900.0 | nM | 4.21 |
| CHEMBL609896 | — | IC50 | = | 196000.0 | nM | - |