Assay Detail
Binding
CHEMBL1072653
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Inhibition of MK2
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
MAP kinase-activated protein kinase 2 (CHEMBL2208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.19 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590109 | — | — | 1 | 7.72 |
| CHEMBL594090 | — | — | 1 | 7.70 |
| CHEMBL592030 | — | — | 1 | 7.46 |
| CHEMBL590612 | — | — | 1 | 7.43 |
| CHEMBL603322 | — | — | 1 | 7.39 |
| CHEMBL591797 | — | — | 1 | 7.25 |
| CHEMBL600081 | — | — | 1 | 6.80 |
| CHEMBL592288 | — | — | 1 | 6.80 |
| CHEMBL591329 | — | — | 1 | 6.58 |
| CHEMBL590834 | — | — | 1 | 6.51 |
| CHEMBL595933 | — | — | 1 | 6.31 |
| CHEMBL589650 | — | — | 1 | 6.14 |
| CHEMBL591783 | — | — | 1 | 6.09 |
| CHEMBL592031 | — | — | 1 | 6.02 |
| CHEMBL590110 | — | — | 1 | 5.89 |
| CHEMBL591071 | — | — | 1 | 5.85 |
| CHEMBL591305 | — | — | 1 | 5.80 |
| CHEMBL589853 | — | — | 1 | 5.72 |
| CHEMBL596588 | — | — | 1 | 5.72 |
| CHEMBL589626 | — | — | 1 | 5.47 |
| CHEMBL591328 | — | — | 1 | 5.27 |
| CHEMBL585958 | — | — | 1 | 5.04 |
| CHEMBL584617 | — | — | 1 | 4.85 |
| CHEMBL584423 | — | — | 1 | 4.62 |
| CHEMBL584640 | — | — | 1 | 4.31 |
| CHEMBL605922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590109 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL594090 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL592030 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL590612 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL603322 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL591797 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL600081 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL592288 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL591329 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL590834 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL595933 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL589650 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL591783 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL592031 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL590110 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL591071 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL591305 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL589853 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL596588 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL589626 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL591328 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL585958 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL584617 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL584423 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL584640 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL605922 | — | IC50 | > | 50000.0 | nM | - |