Assay Detail
Binding
CHEMBL1073017
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Inhibition of 26S proteasome beta 5 using LLVY as substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.61 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL578478 | — | — | 1 | 9.00 |
| CHEMBL578885 | — | — | 1 | 8.70 |
| CHEMBL579296 | — | — | 1 | 8.52 |
| CHEMBL592161 | — | — | 1 | 7.51 |
| CHEMBL591777 | — | — | 1 | 7.00 |
| CHEMBL578486 | — | — | 1 | 6.89 |
| CHEMBL577867 | — | — | 1 | 6.70 |
| CHEMBL578518 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL578478 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL578885 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL579296 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL592161 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL591777 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL578486 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL577867 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL578518 | — | IC50 | = | 300.0 | nM | 6.52 |