Assay Detail
Binding
CHEMBL1073129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant COX2 by enzyme immunoassay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.44 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.92 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.96 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 5.62 |
| CHEMBL601016 | — | — | 1 | 5.12 |
| CHEMBL601015 | — | — | 1 | 4.89 |
| CHEMBL602675 | — | — | 1 | 4.81 |
| CHEMBL602676 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL25 | ASPIRIN | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL601016 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL601015 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL602675 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL602676 | — | IC50 | = | 16800.0 | nM | 4.78 |