Assay Detail
Binding
CHEMBL1073376
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Inhibition of Aurora-A by microplate scintillation counting
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.71 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593987 | — | — | 1 | 8.05 |
| CHEMBL595615 | — | — | 1 | 7.85 |
| CHEMBL596292 | — | — | 1 | 7.62 |
| CHEMBL594228 | — | — | 1 | 7.58 |
| CHEMBL604992 | — | — | 1 | 7.58 |
| CHEMBL593274 | — | — | 1 | 7.57 |
| CHEMBL593275 | — | — | 1 | 7.27 |
| CHEMBL593908 | — | — | 1 | 7.22 |
| CHEMBL593306 | — | — | 1 | 7.21 |
| CHEMBL593221 | — | — | 1 | 7.19 |
| CHEMBL595143 | — | — | 1 | 7.09 |
| CHEMBL593909 | — | — | 1 | 7.07 |
| CHEMBL606466 | — | — | 1 | 7.04 |
| CHEMBL593292 | — | — | 1 | 6.96 |
| CHEMBL593860 | — | — | 1 | 6.92 |
| CHEMBL595373 | — | — | 1 | 6.77 |
| CHEMBL593760 | — | — | 1 | 6.70 |
| CHEMBL604483 | — | — | 1 | 6.66 |
| CHEMBL596087 | — | — | 1 | 6.64 |
| CHEMBL595142 | — | — | 1 | 6.64 |
| CHEMBL593245 | — | — | 1 | 6.54 |
| CHEMBL604485 | — | — | 1 | 6.52 |
| CHEMBL595406 | — | — | 1 | 6.47 |
| CHEMBL473556 | — | — | 1 | 6.46 |
| CHEMBL594661 | — | — | 1 | 6.41 |
| CHEMBL593971 | — | — | 1 | 6.40 |
| CHEMBL604893 | — | — | 1 | 6.16 |
| CHEMBL593294 | — | — | 1 | 6.10 |
| CHEMBL593905 | — | — | 1 | 5.92 |
| CHEMBL593910 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593987 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL595615 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL596292 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL594228 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL604992 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL593274 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL593275 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL593908 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL593306 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL593221 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL595143 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL593909 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL606466 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL593292 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL593860 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL595373 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL593760 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL604483 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL596087 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL595142 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL593245 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL604485 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL595406 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL473556 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL594661 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL593971 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL604893 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL593294 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL593905 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL593910 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL593911 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL593770 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL514942 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL595374 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL596059 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL593293 | — | IC50 | > | 10000.0 | nM | - |