Assay Detail
Binding
CHEMBL1073402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radioligand from human adenosine A3 receptor expressed in cells by topcount microplate scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.87 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609578 | — | — | 1 | 6.44 |
| CHEMBL603748 | — | — | 1 | 6.13 |
| CHEMBL608383 | — | — | 1 | 6.05 |
| CHEMBL594136 | — | — | 1 | 5.94 |
| CHEMBL594455 | — | — | 1 | 5.79 |
| CHEMBL594363 | — | — | 1 | 5.68 |
| CHEMBL596308 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609578 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL603748 | — | Ki | = | 741.0 | nM | 6.13 |
| CHEMBL608383 | — | Ki | = | 896.0 | nM | 6.05 |
| CHEMBL594136 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL594455 | — | Ki | = | 1627.0 | nM | 5.79 |
| CHEMBL594363 | — | Ki | = | 2104.0 | nM | 5.68 |
| CHEMBL596308 | — | Ki | = | 9090.0 | nM | 5.04 |