Assay Detail
Binding
CHEMBL1073480
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Inhibition of human recombinant BACE1 after 60 mins by fluorescence assay
13
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biotransformation of isoimperatorin and imperatorin by Glomerella cingulata and beta-secretase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 7 | - | - |
| IC50 | 6 | 4.66 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602233 | — | — | 2 | 4.79 |
| CHEMBL453805 | PENTOSALEN | -1.0 | 2 | 4.52 |
| CHEMBL448060 | ISOIMPERATORIN | — | 2 | - |
| CHEMBL1192 | XANTHOTOXOL | — | 1 | - |
| CHEMBL589416 | — | — | 2 | - |
| CHEMBL592382 | — | — | 2 | - |
| CHEMBL589100 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602233 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL453805 | PENTOSALEN | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL448060 | ISOIMPERATORIN | Inhibition | - | % | - | |
| CHEMBL1192 | XANTHOTOXOL | Inhibition | - | % | - | |
| CHEMBL453805 | PENTOSALEN | Inhibition | - | % | - | |
| CHEMBL602233 | — | Inhibition | - | % | - | |
| CHEMBL589416 | — | Inhibition | - | % | - | |
| CHEMBL592382 | — | Inhibition | - | % | - | |
| CHEMBL589100 | — | Inhibition | - | % | - | |
| CHEMBL448060 | ISOIMPERATORIN | IC50 | = | 244200.0 | nM | - |
| CHEMBL589100 | — | IC50 | = | 185600.0 | nM | - |
| CHEMBL592382 | — | IC50 | = | 203300.0 | nM | - |
| CHEMBL589416 | — | IC50 | = | 203300.0 | nM | - |