Assay Detail
Binding
CHEMBL1073573
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Inhibition of HDAC6
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.62 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.19 |
| CHEMBL589918 | — | — | 1 | 6.62 |
| CHEMBL589311 | — | — | 1 | 6.55 |
| CHEMBL598363 | — | — | 1 | 6.48 |
| CHEMBL589906 | — | — | 1 | 6.47 |
| CHEMBL592719 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL589918 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL589311 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL598363 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL589906 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL592719 | — | IC50 | = | 410.0 | nM | 6.39 |