Assay Detail
Functional
CHEMBL1073796
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Decrease in bone resorption assessed as corrected bone resorption measured as ratio of bone resorption IC50 x humanized rabbit cathepsin K IC50 to rabbit cathepsin K IC50 equation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Bone element |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.93 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 8.30 |
| CHEMBL599272 | — | — | 1 | 8.15 |
| CHEMBL605341 | — | — | 1 | 8.10 |
| CHEMBL600793 | — | — | 1 | 8.10 |
| CHEMBL603899 | — | — | 1 | 8.00 |
| CHEMBL597018 | — | — | 1 | 8.00 |
| CHEMBL598502 | — | — | 1 | 7.92 |
| CHEMBL605122 | — | — | 1 | 7.89 |
| CHEMBL598298 | — | — | 1 | 7.85 |
| CHEMBL597426 | — | — | 1 | 7.46 |
| CHEMBL598299 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481611 | ODANACATIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL599272 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL605341 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL600793 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL603899 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL597018 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL598502 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL605122 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL598298 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL597426 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL598299 | — | IC50 | = | 35.0 | nM | 7.46 |