Assay Detail
Binding
CHEMBL1074041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [I125]RTI-55 from human DAT transfected in human HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.07 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234706 | — | — | 1 | 6.54 |
| CHEMBL609908 | — | — | 1 | 6.21 |
| CHEMBL552167 | — | — | 1 | 6.16 |
| CHEMBL196468 | — | — | 1 | 5.38 |
| CHEMBL180630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234706 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL609908 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL552167 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL196468 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL180630 | — | IC50 | - | — | - |