Assay Detail
Binding
CHEMBL1074174
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Inhibition of Escherichia coli DNA gyrase B ATPase activity
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In silico discovery of 2-amino-4-(2,4-dihydroxyphenyl)thiazoles as novel inhibitors of DNA gyrase B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.98 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590664 | — | — | 1 | 8.82 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 8.52 |
| CHEMBL431453 | — | — | 1 | 7.16 |
| CHEMBL157831 | — | — | 1 | 6.80 |
| CHEMBL156813 | — | — | 1 | 6.31 |
| CHEMBL157769 | — | — | 1 | 6.11 |
| CHEMBL239103 | — | — | 1 | 4.60 |
| CHEMBL599385 | — | — | 1 | 4.44 |
| CHEMBL596726 | — | — | 1 | 4.41 |
| CHEMBL599386 | — | — | 1 | 4.34 |
| CHEMBL590969 | — | — | 1 | 4.25 |
| CHEMBL597529 | — | — | 1 | - |
| CHEMBL596918 | — | — | 1 | - |
| CHEMBL600247 | — | — | 1 | - |
| CHEMBL599169 | — | — | 1 | - |
| CHEMBL178130 | — | — | 1 | - |
| CHEMBL599170 | — | — | 1 | - |
| CHEMBL602730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590664 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL36506 | NOVOBIOCIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL431453 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL157831 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL156813 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL157769 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL239103 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL599385 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL596726 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL599386 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL590969 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL597529 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL596918 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL600247 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL599169 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL178130 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL599170 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL602730 | — | IC50 | > | 500000.0 | nM | - |