Assay Detail
Binding
CHEMBL1074266
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Inhibition of human CA2 by stopped-flow CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.82 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL441343 | PARABEN | — | 1 | 6.06 |
| CHEMBL66879 | COUMARIC ACID | — | 1 | 6.01 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 5.79 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 5.66 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | 5.65 |
| CHEMBL32749 | FERULATE | -1.0 | 1 | 5.62 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.59 |
| CHEMBL1414 | SYRINGIC ACID | — | 1 | 5.50 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 5.26 |
| CHEMBL280998 | CATECHOL | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL441343 | PARABEN | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL66879 | COUMARIC ACID | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL145 | CAFFEIC ACID | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL6246 | ELLAGIC ACID | Ki | = | 2180.0 | nM | 5.66 |
| CHEMBL288114 | GALLIC ACID | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL32749 | FERULATE | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL50 | QUERCETIN | Ki | = | 2540.0 | nM | 5.59 |
| CHEMBL1414 | SYRINGIC ACID | Ki | = | 3190.0 | nM | 5.50 |
| CHEMBL14060 | PHENOL | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL280998 | CATECHOL | Ki | = | 9900.0 | nM | 5.00 |