Assay Detail
Binding
CHEMBL1074491
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Inhibition of GCAP by analogous luminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Alkaline phosphatase, germ cell type (CHEMBL3402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of selective inhibitors of placental alkaline phosphatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.46 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592869 | — | — | 1 | 6.22 |
| CHEMBL349641 | — | — | 1 | 5.92 |
| CHEMBL607856 | — | — | 1 | 5.77 |
| CHEMBL608723 | — | — | 1 | 5.57 |
| CHEMBL597837 | — | — | 1 | 5.21 |
| CHEMBL597055 | — | — | 1 | 5.03 |
| CHEMBL589756 | — | — | 1 | 4.52 |
| CHEMBL610781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592869 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL349641 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL607856 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL608723 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL597837 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL597055 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL589756 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL610781 | — | IC50 | - | — | - |