Assay Detail
Binding
CHEMBL1074499
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Inhibition of HIV1 reverse transcriptase K103N mutant by RNA-dependent DNA polymerase activity assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.65 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.70 |
| CHEMBL234401 | — | — | 1 | 6.40 |
| CHEMBL600615 | — | — | 1 | 6.05 |
| CHEMBL601219 | — | — | 1 | 5.58 |
| CHEMBL600411 | — | — | 1 | 5.55 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.40 |
| CHEMBL603275 | — | — | 1 | 5.17 |
| CHEMBL592877 | — | — | 1 | 5.00 |
| CHEMBL601866 | — | — | 1 | 4.96 |
| CHEMBL601007 | — | — | 1 | - |
| CHEMBL603276 | — | — | 1 | - |
| CHEMBL601867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL234401 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL600615 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL601219 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL600411 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL603275 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL592877 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL601866 | — | IC50 | = | 10920.0 | nM | 4.96 |
| CHEMBL601007 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL603276 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL601867 | — | IC50 | > | 40000.0 | nM | - |