Assay Detail
Binding
CHEMBL1074501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin assembly by immunofluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9859 | — | — | 1 | 6.34 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.89 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9859 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL107 | COLCHICINE | IC50 | = | 2600.0 | nM | 5.58 |