Assay Detail
Binding
CHEMBL1074686
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Inhibition of FBPase in mouse liver
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 4.80 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL591083 | — | — | 1 | 5.62 |
| CHEMBL605615 | — | — | 1 | 5.55 |
| CHEMBL589863 | — | — | 1 | 5.50 |
| CHEMBL590363 | — | — | 1 | 5.28 |
| CHEMBL590361 | — | — | 1 | 5.26 |
| CHEMBL601267 | — | — | 1 | 5.20 |
| CHEMBL573056 | — | — | 1 | 5.19 |
| CHEMBL600654 | — | — | 1 | 5.09 |
| CHEMBL590111 | — | — | 1 | 5.05 |
| CHEMBL601691 | — | — | 1 | 5.05 |
| CHEMBL602789 | — | — | 1 | 5.04 |
| CHEMBL591316 | — | — | 1 | 5.00 |
| CHEMBL611631 | — | — | 1 | 5.00 |
| CHEMBL590360 | — | — | 1 | 5.00 |
| CHEMBL585620 | — | — | 1 | 4.92 |
| CHEMBL590359 | — | — | 1 | 4.89 |
| CHEMBL590840 | — | — | 1 | 4.85 |
| CHEMBL590113 | — | — | 1 | 4.85 |
| CHEMBL590362 | — | — | 1 | 4.85 |
| CHEMBL591317 | — | — | 1 | 4.82 |
| CHEMBL590839 | — | — | 1 | 4.75 |
| CHEMBL589862 | — | — | 1 | 4.72 |
| CHEMBL590597 | — | — | 1 | 4.72 |
| CHEMBL589861 | — | — | 1 | 4.64 |
| CHEMBL593282 | — | — | 1 | 4.62 |
| CHEMBL595150 | — | — | 1 | 4.62 |
| CHEMBL585961 | — | — | 1 | 4.57 |
| CHEMBL589137 | — | — | 1 | 4.50 |
| CHEMBL589865 | — | — | 1 | 4.47 |
| CHEMBL600653 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL591083 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL605615 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL589863 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL590363 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL590361 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL601267 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL573056 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL600654 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL590111 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL601691 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL602789 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL591316 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL590360 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL611631 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL585620 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL590359 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL590840 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL590113 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL590362 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL591317 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL590839 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL590597 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL589862 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL589861 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL593282 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL595150 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL585961 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL589137 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL589865 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL600653 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL595149 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL594444 | — | EC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL595529 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL608398 | — | EC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL610462 | — | EC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL594445 | — | EC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL595304 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL594668 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL607540 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL595067 | — | EC50 | = | 118000.0 | nM | - |