Assay Detail
Functional
CHEMBL1100183
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Cytotoxicity against human HT-29 cells after 72 hrs by FMCA method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.90 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | 1.0 | 1 | 6.36 |
| CHEMBL399336 | CONVALLATOXIN | — | 1 | 6.26 |
| CHEMBL600325 | PROSCILLARIDIN | 2.0 | 1 | 6.26 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 5.85 |
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 5.39 |
| CHEMBL404811 | DIGITONIN | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL399336 | CONVALLATOXIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL600325 | PROSCILLARIDIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL254219 | DIGITOXIN | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL404811 | DIGITONIN | IC50 | = | 5600.0 | nM | 5.25 |