Assay Detail
Binding
CHEMBL1100196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 TAT transfected to human HeLa cells assessed as decrease in luminescence after 48 hrs by duel luciferase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein Tat (CHEMBL4011) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) |
Publication
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.98 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1075826 | — | — | 1 | 6.05 |
| CHEMBL1075815 | — | — | 1 | 5.22 |
| CHEMBL1075830 | — | — | 1 | 5.16 |
| CHEMBL1075824 | — | — | 1 | 5.00 |
| CHEMBL1075821 | — | — | 1 | 4.92 |
| CHEMBL1075825 | — | — | 1 | 4.80 |
| CHEMBL1081563 | — | — | 1 | 4.72 |
| CHEMBL1075829 | — | — | 1 | 4.52 |
| CHEMBL1075823 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1075826 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1075815 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1075830 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1075824 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1075821 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1075825 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1081563 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1075829 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1075823 | — | IC50 | = | 35000.0 | nM | 4.46 |