Assay Detail
Binding
CHEMBL1100282
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Inhibition of HSP90alpha
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Heat shock protein 90: inhibitors in clinical trials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.39 | 8.77 |
| IC50 | 1 | 8.11 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467399 | BIIB021 | 2.0 | 1 | 8.77 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.34 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 2 | 8.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467399 | BIIB021 | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL109480 | TANESPIMYCIN | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL252164 | LUMINESPIB | Ki | = | 9.0 | nM | 8.05 |