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Assay Detail

CHEMBL1100425

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of H+/K+ ATPase at pH 7.4
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).
Panchal T, Bailey N, Bamford M, Demont E, Elliott R, Farre-Gutierrez I, Garton N, Hayhow T, Hutley G, Naylor A.
Bioorg Med Chem Lett (2009) 19 : 6813 -6817
PubMed 19846298 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 6.58 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1076210 1 9.40
CHEMBL1079413 1 9.00
CHEMBL1079581 1 8.40
CHEMBL1076536 1 7.60
CHEMBL1080717 1 7.60
CHEMBL1080088 1 7.50
CHEMBL1079958 1 7.40
CHEMBL47529 1 7.40
CHEMBL1076245 1 7.40
CHEMBL1080472 1 7.40
CHEMBL256398 1 7.10
CHEMBL238146 1 7.00
CHEMBL1080803 1 6.80
CHEMBL1079414 1 6.80
CHEMBL1087758 1 6.80
CHEMBL1076192 1 6.80
CHEMBL1080982 1 6.60
CHEMBL1079957 1 6.50
CHEMBL497011 LINAPRAZAN 2.0 1 6.50
CHEMBL1080473 1 6.30
CHEMBL1080719 1 6.10
CHEMBL1081504 1 5.90
CHEMBL1079436 1 5.90
CHEMBL1081505 1 5.50
CHEMBL1081870 1 5.30
CHEMBL1079437 1 5.10
CHEMBL1079703 1 4.80
CHEMBL1081684 1 4.50
CHEMBL1080551 1 4.10
CHEMBL1080718 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1076210 IC50 = 0.3981 nM 9.40
CHEMBL1079413 IC50 = 1.0 nM 9.00
CHEMBL1079581 IC50 = 3.981 nM 8.40
CHEMBL1076536 IC50 = 25.12 nM 7.60
CHEMBL1080717 IC50 = 25.12 nM 7.60
CHEMBL1080088 IC50 = 31.62 nM 7.50
CHEMBL1079958 IC50 = 39.81 nM 7.40
CHEMBL47529 IC50 = 39.81 nM 7.40
CHEMBL1076245 IC50 = 39.81 nM 7.40
CHEMBL1080472 IC50 = 39.81 nM 7.40
CHEMBL256398 IC50 = 79.43 nM 7.10
CHEMBL238146 IC50 = 100.0 nM 7.00
CHEMBL1076192 IC50 = 158.49 nM 6.80
CHEMBL1087758 IC50 = 158.49 nM 6.80
CHEMBL1079414 IC50 = 158.49 nM 6.80
CHEMBL1080803 IC50 = 158.49 nM 6.80
CHEMBL1080982 IC50 = 251.19 nM 6.60
CHEMBL1079957 IC50 = 316.23 nM 6.50
CHEMBL497011 LINAPRAZAN IC50 = 316.23 nM 6.50
CHEMBL1080473 IC50 = 501.19 nM 6.30
CHEMBL1080719 IC50 = 794.33 nM 6.10
CHEMBL1081504 IC50 = 1258.93 nM 5.90
CHEMBL1079436 IC50 = 1258.93 nM 5.90
CHEMBL1081505 IC50 = 3162.28 nM 5.50
CHEMBL1081870 IC50 = 5011.87 nM 5.30
CHEMBL1079437 IC50 = 7943.28 nM 5.10
CHEMBL1079703 IC50 = 15848.93 nM 4.80
CHEMBL1081684 IC50 = 31622.78 nM 4.50
CHEMBL1080551 IC50 = 79432.82 nM 4.10
CHEMBL1080718 IC50 = 100000.0 nM 4.00
CHEMBL1081199 IC50 > 100000.0 nM -
CHEMBL1081200 IC50 > 100000.0 nM -