Assay Detail
Binding
CHEMBL1100426
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Inhibition of H+/K+ ATPase in parietal cells assessed as inhibition of pentagastrin-stimulated [14C]aminopyrine accumulation
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.95 | 7.78 |
| pIC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47529 | — | — | 1 | 7.78 |
| CHEMBL238146 | — | — | 1 | 7.63 |
| CHEMBL1081505 | — | — | 1 | 7.35 |
| CHEMBL497011 | LINAPRAZAN | 2.0 | 1 | 7.25 |
| CHEMBL1081504 | — | — | 1 | 7.20 |
| CHEMBL1076210 | — | — | 1 | 7.15 |
| CHEMBL1081870 | — | — | 1 | 7.13 |
| CHEMBL1080982 | — | — | 1 | 7.10 |
| CHEMBL1080717 | — | — | 1 | 6.85 |
| CHEMBL1079957 | — | — | 1 | 6.80 |
| CHEMBL1076245 | — | — | 1 | 6.80 |
| CHEMBL1079958 | — | — | 1 | 6.70 |
| CHEMBL1079436 | — | — | 1 | 6.70 |
| CHEMBL1080803 | — | — | 1 | 6.60 |
| CHEMBL256398 | — | — | 1 | 6.55 |
| CHEMBL1087758 | — | — | 1 | 6.55 |
| CHEMBL1080473 | — | — | 1 | 6.50 |
| CHEMBL1079437 | — | — | 1 | 6.50 |
| CHEMBL1080472 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47529 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL238146 | — | IC50 | = | 23.44 | nM | 7.63 |
| CHEMBL1081505 | — | IC50 | = | 44.67 | nM | 7.35 |
| CHEMBL497011 | LINAPRAZAN | IC50 | = | 56.23 | nM | 7.25 |
| CHEMBL1081504 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1076210 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL1081870 | — | IC50 | = | 74.13 | nM | 7.13 |
| CHEMBL1080982 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL1080717 | — | IC50 | = | 141.25 | nM | 6.85 |
| CHEMBL1079957 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1076245 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1079958 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL1079436 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL1080803 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL256398 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL1087758 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL1080473 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1079437 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1080472 | — | pIC50 | - | — | - |