Assay Detail
Functional
CHEMBL1100446
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Antiviral activity against HCV 1b after 72 hrs by replicon assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.69 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1085893 | — | — | 1 | 8.70 |
| CHEMBL1088051 | — | — | 1 | 8.52 |
| CHEMBL1088052 | — | — | 1 | 8.40 |
| CHEMBL1087427 | — | — | 1 | 8.10 |
| CHEMBL1085677 | — | — | 1 | 8.05 |
| CHEMBL1084672 | — | — | 1 | 7.89 |
| CHEMBL1082853 | — | — | 1 | 7.82 |
| CHEMBL1077125 | — | — | 1 | 7.54 |
| CHEMBL372357 | — | — | 1 | 7.42 |
| CHEMBL1085894 | — | — | 1 | 7.41 |
| CHEMBL1084662 | — | — | 1 | 7.32 |
| CHEMBL1082873 | — | — | 1 | 7.24 |
| CHEMBL1088060 | — | — | 1 | 7.09 |
| CHEMBL1084399 | — | — | 1 | 6.68 |
| CHEMBL1085678 | — | — | 1 | 6.68 |
| CHEMBL1088211 | — | — | 1 | 6.66 |
| CHEMBL1088201 | — | — | 1 | 6.63 |
| CHEMBL1086918 | — | — | 1 | 6.57 |
| CHEMBL1083504 | — | — | 1 | 6.48 |
| CHEMBL1082874 | — | — | 1 | 6.47 |
| CHEMBL1084408 | — | — | 1 | 6.42 |
| CHEMBL176058 | — | — | 1 | 6.38 |
| CHEMBL1085435 | — | — | 1 | 6.31 |
| CHEMBL1082854 | — | — | 1 | 6.25 |
| CHEMBL1088061 | — | — | 1 | 6.09 |
| CHEMBL1088212 | — | — | 1 | 5.90 |
| CHEMBL1088342 | — | — | 1 | 5.86 |
| CHEMBL1088200 | — | — | 1 | 5.79 |
| CHEMBL1085436 | — | — | 1 | 5.75 |
| CHEMBL1087428 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1085893 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1088051 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1088052 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1087427 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1085677 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1084672 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1082853 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1077125 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL372357 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1085894 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1084662 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1082873 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1088060 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1084399 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL1085678 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL1088211 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL1088201 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1086918 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL1083504 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL1082874 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL1084408 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL176058 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL1085435 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL1082854 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL1088061 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL1088212 | — | IC50 | = | 1247.0 | nM | 5.90 |
| CHEMBL1088342 | — | IC50 | = | 1394.0 | nM | 5.86 |
| CHEMBL1088200 | — | IC50 | = | 1604.0 | nM | 5.79 |
| CHEMBL1085436 | — | IC50 | = | 1784.0 | nM | 5.75 |
| CHEMBL1087428 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1088202 | — | IC50 | = | 2295.0 | nM | 5.64 |
| CHEMBL1083505 | — | IC50 | = | 2321.0 | nM | 5.63 |
| CHEMBL1084406 | — | IC50 | = | 2625.0 | nM | 5.58 |
| CHEMBL1086917 | — | IC50 | = | 3742.0 | nM | 5.43 |
| CHEMBL1083812 | — | IC50 | = | 5141.0 | nM | 5.29 |
| CHEMBL1084405 | — | IC50 | = | 5195.0 | nM | 5.28 |
| CHEMBL1087562 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1086643 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1087794 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1085891 | — | IC50 | - | — | - | |
| CHEMBL1085180 | — | IC50 | - | — | - | |
| CHEMBL1084407 | — | IC50 | > | 20000.0 | nM | - |