Assay Detail
Functional
CHEMBL1100447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV 1b after 72 hrs by replicon assay in presence of HSA and AAG
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.08 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088051 | — | — | 1 | 5.99 |
| CHEMBL1085893 | — | — | 1 | 5.83 |
| CHEMBL1087427 | — | — | 1 | 5.62 |
| CHEMBL1082853 | — | — | 1 | 5.58 |
| CHEMBL1084672 | — | — | 1 | 5.51 |
| CHEMBL1085677 | — | — | 1 | 5.32 |
| CHEMBL1086918 | — | — | 1 | 5.27 |
| CHEMBL1077125 | — | — | 1 | 5.10 |
| CHEMBL372357 | — | — | 1 | 4.61 |
| CHEMBL1088211 | — | — | 1 | 4.35 |
| CHEMBL1085894 | — | — | 1 | 4.30 |
| CHEMBL1082873 | — | — | 1 | 4.30 |
| CHEMBL1088052 | — | — | 1 | 4.30 |
| CHEMBL1087794 | — | — | 1 | - |
| CHEMBL1085436 | — | — | 1 | - |
| CHEMBL1085435 | — | — | 1 | - |
| CHEMBL1085180 | — | — | 1 | - |
| CHEMBL1083812 | — | — | 1 | - |
| CHEMBL1083505 | — | — | 1 | - |
| CHEMBL1083504 | — | — | 1 | - |
| CHEMBL1087562 | — | — | 1 | - |
| CHEMBL1082854 | — | — | 1 | - |
| CHEMBL1086917 | — | — | 1 | - |
| CHEMBL1082874 | — | — | 1 | - |
| CHEMBL1088201 | — | — | 1 | - |
| CHEMBL1088202 | — | — | 1 | - |
| CHEMBL1087428 | — | — | 1 | - |
| CHEMBL1085678 | — | — | 1 | - |
| CHEMBL1084399 | — | — | 1 | - |
| CHEMBL1084662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088051 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL1085893 | — | IC50 | = | 1484.0 | nM | 5.83 |
| CHEMBL1087427 | — | IC50 | = | 2388.0 | nM | 5.62 |
| CHEMBL1082853 | — | IC50 | = | 2646.0 | nM | 5.58 |
| CHEMBL1084672 | — | IC50 | = | 3097.0 | nM | 5.51 |
| CHEMBL1085677 | — | IC50 | = | 4737.0 | nM | 5.32 |
| CHEMBL1086918 | — | IC50 | = | 5358.0 | nM | 5.27 |
| CHEMBL1077125 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL372357 | — | IC50 | = | 24461.0 | nM | 4.61 |
| CHEMBL1088211 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1088052 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1082873 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1085894 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1085436 | — | IC50 | - | — | - | |
| CHEMBL1087794 | — | IC50 | - | — | - | |
| CHEMBL1088212 | — | IC50 | - | — | - | |
| CHEMBL1088342 | — | IC50 | - | — | - | |
| CHEMBL1085891 | — | IC50 | - | — | - | |
| CHEMBL1084405 | — | IC50 | - | — | - | |
| CHEMBL1084406 | — | IC50 | - | — | - | |
| CHEMBL1084407 | — | IC50 | - | — | - | |
| CHEMBL1084408 | — | IC50 | - | — | - | |
| CHEMBL1086643 | — | IC50 | - | — | - | |
| CHEMBL1088060 | — | IC50 | - | — | - | |
| CHEMBL1088061 | — | IC50 | - | — | - | |
| CHEMBL1088200 | — | IC50 | - | — | - | |
| CHEMBL176058 | — | IC50 | - | — | - | |
| CHEMBL1085435 | — | IC50 | - | — | - | |
| CHEMBL1085180 | — | IC50 | - | — | - | |
| CHEMBL1083812 | — | IC50 | - | — | - | |
| CHEMBL1083505 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1083504 | — | IC50 | - | — | - | |
| CHEMBL1087562 | — | IC50 | - | — | - | |
| CHEMBL1082854 | — | IC50 | - | — | - | |
| CHEMBL1086917 | — | IC50 | - | — | - | |
| CHEMBL1082874 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1088201 | — | IC50 | - | — | - | |
| CHEMBL1088202 | — | IC50 | - | — | - | |
| CHEMBL1087428 | — | IC50 | - | — | - | |
| CHEMBL1085678 | — | IC50 | - | — | - | |
| CHEMBL1084399 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1084662 | — | IC50 | - | — | - |