Assay Detail
Functional
CHEMBL1100798
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Antiproliferative activity in human MCF7 cells after 96 hrs by MTT assay in presence of acacetin
3
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.82 | 4.82 |
| Activity | 1 | - | - |
| IC25 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72637 | CIRSILIOL | — | 2 | 4.82 |
| CHEMBL487402 | EUPATORIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72637 | CIRSILIOL | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL487402 | EUPATORIN | Activity | - | — | - | |
| CHEMBL72637 | CIRSILIOL | IC25 | = | 5.0 | uM | - |