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Assay Detail

CHEMBL1101183

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human dCK
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Deoxycytidine kinase (CHEMBL2447)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase.
Tarver JE, Jessop TC, Carlsen M, Augeri DJ, Fu Q, Healy JP, Heim-Riether A, Xu A, Taylor JA, Shen M, Keyes PE, David Kimball S, Yu XC, Miranda M, Liu Q, Swaffield JC, Nouraldeen A, Wilson AG, Finch R, Jhaver K, Foushee AM, Anderson S, Oravecz T, Carson KG.
Bioorg Med Chem Lett (2009) 19 : 6780 -6783
PubMed 19836229 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 8.05 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1081002 1 9.15
CHEMBL1081903 1 9.00
CHEMBL1080093 1 9.00
CHEMBL1081904 1 8.70
CHEMBL1079768 1 8.52
CHEMBL1080636 1 8.52
CHEMBL1079906 1 8.52
CHEMBL1080443 1 8.52
CHEMBL1081350 1 8.52
CHEMBL1079380 1 8.40
CHEMBL1079379 1 8.40
CHEMBL1081727 1 8.30
CHEMBL1080092 1 8.30
CHEMBL1079601 1 8.30
CHEMBL1081901 1 8.22
CHEMBL1079603 1 8.05
CHEMBL1081544 1 8.05
CHEMBL1079735 1 8.00
CHEMBL1080818 1 8.00
CHEMBL1079907 1 7.89
CHEMBL1081351 1 7.72
CHEMBL1079602 1 7.68
CHEMBL1080817 1 7.68
CHEMBL1081352 1 7.66
CHEMBL1076272 1 7.64
CHEMBL1079770 1 7.48
CHEMBL1079585 1 7.47
CHEMBL1081561 1 7.42
CHEMBL1080829 1 7.20
CHEMBL1079769 1 7.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1081002 IC50 = 0.7 nM 9.15
CHEMBL1081903 IC50 = 1.0 nM 9.00
CHEMBL1080093 IC50 = 1.0 nM 9.00
CHEMBL1081904 IC50 = 2.0 nM 8.70
CHEMBL1079768 IC50 = 3.0 nM 8.52
CHEMBL1080636 IC50 = 3.0 nM 8.52
CHEMBL1079906 IC50 = 3.0 nM 8.52
CHEMBL1080443 IC50 = 3.0 nM 8.52
CHEMBL1081350 IC50 = 3.0 nM 8.52
CHEMBL1079380 IC50 = 4.0 nM 8.40
CHEMBL1079379 IC50 = 4.0 nM 8.40
CHEMBL1081727 IC50 = 5.0 nM 8.30
CHEMBL1080092 IC50 = 5.0 nM 8.30
CHEMBL1079601 IC50 = 5.0 nM 8.30
CHEMBL1081901 IC50 = 6.0 nM 8.22
CHEMBL1081544 IC50 = 9.0 nM 8.05
CHEMBL1079603 IC50 = 9.0 nM 8.05
CHEMBL1079735 IC50 = 10.0 nM 8.00
CHEMBL1080818 IC50 = 10.0 nM 8.00
CHEMBL1079907 IC50 = 13.0 nM 7.89
CHEMBL1081351 IC50 = 19.0 nM 7.72
CHEMBL1079602 IC50 = 21.0 nM 7.68
CHEMBL1080817 IC50 = 21.0 nM 7.68
CHEMBL1081352 IC50 = 22.0 nM 7.66
CHEMBL1076272 IC50 = 23.0 nM 7.64
CHEMBL1079770 IC50 = 33.0 nM 7.48
CHEMBL1079585 IC50 = 34.0 nM 7.47
CHEMBL1081561 IC50 = 38.0 nM 7.42
CHEMBL1080829 IC50 = 63.0 nM 7.20
CHEMBL1079769 IC50 = 95.0 nM 7.02
CHEMBL1081560 IC50 = 720.0 nM 6.14
CHEMBL1076257 IC50 = 120000.0 nM -
CHEMBL1081559 IC50 = 510000.0 nM -