Assay Detail
Functional
CHEMBL1101461
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Agonist activity at human S1P1 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
S1P receptor mediated activity of FTY720 phosphate mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.52 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190006 | — | — | 1 | 9.85 |
| CHEMBL1084929 | — | — | 1 | 9.07 |
| CHEMBL1086172 | — | — | 1 | 7.72 |
| CHEMBL1086170 | — | — | 1 | 7.70 |
| CHEMBL1086171 | — | — | 1 | 7.36 |
| CHEMBL1084930 | — | — | 1 | 6.96 |
| CHEMBL1077288 | — | — | 1 | 6.62 |
| CHEMBL1083841 | — | — | 1 | 6.34 |
| CHEMBL1085191 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190006 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL1084929 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL1086172 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1086170 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1086171 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1084930 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1077288 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1083841 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1085191 | — | EC50 | = | 960.0 | nM | 6.02 |