Assay Detail
Binding
CHEMBL1101480
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Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK-Net6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.00 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204411 | — | — | 1 | 8.52 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 8.52 |
| CHEMBL1204412 | — | — | 1 | 8.30 |
| CHEMBL1204414 | — | — | 1 | 7.96 |
| CHEMBL1204410 | — | — | 1 | 7.92 |
| CHEMBL1099373 | — | — | 1 | 7.60 |
| CHEMBL1204413 | — | — | 1 | 7.58 |
| CHEMBL1204415 | — | — | 1 | 7.57 |
| CHEMBL1087924 | — | — | 1 | 7.54 |
| CHEMBL1083211 | — | — | 1 | 7.52 |
| CHEMBL1084933 | — | — | 1 | 7.42 |
| CHEMBL1085198 | — | — | 1 | 7.28 |
| CHEMBL1085197 | — | — | 1 | 7.26 |
| CHEMBL1077209 | — | — | 1 | 7.06 |
| CHEMBL1096001 | — | — | 1 | 7.03 |
| CHEMBL1083210 | — | — | 1 | 6.92 |
| CHEMBL1086398 | — | — | 1 | 6.89 |
| CHEMBL1085906 | — | — | 1 | 6.85 |
| CHEMBL1095367 | — | — | 1 | 6.77 |
| CHEMBL1087923 | — | — | 1 | 6.70 |
| CHEMBL1085905 | — | — | 1 | 6.31 |
| CHEMBL1086399 | — | — | 1 | 6.20 |
| CHEMBL1085904 | — | — | 1 | 6.10 |
| CHEMBL1077202 | — | — | 1 | 6.04 |
| CHEMBL1087921 | — | — | 1 | 6.01 |
| CHEMBL1082534 | — | — | 1 | 5.99 |
| CHEMBL1084934 | — | — | 1 | 5.85 |
| CHEMBL1087922 | — | — | 1 | 5.82 |
| CHEMBL1085907 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204411 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1204412 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1204414 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1204410 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1099373 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1204413 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1204415 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1087924 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1083211 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1084933 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1085198 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1085197 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1077209 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1096001 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1083210 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1086398 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1085906 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1095367 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1087923 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1085905 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1086399 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1085904 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1077202 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL1087921 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1082534 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1084934 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1087922 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1085907 | — | IC50 | = | 3550.0 | nM | 5.45 |