Assay Detail
Functional
CHEMBL1101545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHH in mouse Shh Light2 cells after 30 hrs by GLI-responsive bright glo luciferase reporter gene assay
27
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Shh Light II |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ECmax | 14 | - | - |
| EC50 | 13 | 4.75 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473392 | ROBOTNIKININ | — | 2 | 5.40 |
| CHEMBL1087150 | — | — | 2 | 5.40 |
| CHEMBL1087530 | — | — | 2 | 5.16 |
| CHEMBL1081556 | — | — | 2 | 5.00 |
| CHEMBL1080988 | — | — | 2 | 4.82 |
| CHEMBL1079558 | — | — | 2 | 4.82 |
| CHEMBL1088172 | — | — | 2 | 4.82 |
| CHEMBL1080649 | — | — | 2 | 4.70 |
| CHEMBL1080987 | — | — | 2 | 4.52 |
| CHEMBL1076336 | — | — | 2 | 4.51 |
| CHEMBL1080091 | — | — | 2 | 4.22 |
| CHEMBL1079557 | — | — | 2 | 4.22 |
| CHEMBL1076352 | — | — | 2 | 4.16 |
| CHEMBL1087151 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473392 | ROBOTNIKININ | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1087150 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1087530 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1081556 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1080988 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1079558 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1088172 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1080649 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1080987 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1076336 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1079557 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1080091 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1076352 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1080988 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1076336 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1080987 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1080091 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1076352 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1079557 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1079558 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1081556 | — | ECmax | = | 15.6 | uM | - |
| CHEMBL1080649 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL473392 | ROBOTNIKININ | ECmax | = | 62.5 | uM | - |
| CHEMBL1088172 | — | ECmax | = | 125.0 | uM | - |
| CHEMBL1087530 | — | ECmax | = | 62.5 | uM | - |
| CHEMBL1087150 | — | ECmax | = | 15.6 | uM | - |
| CHEMBL1087151 | — | ECmax | = | 125.0 | uM | - |