Assay Detail
Functional
CHEMBL1101679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vesicular stomatitis virus infected in EPT cells assessed as inhibition of virus-induced cytopathic effect treated immediately after viral infection measured after 24 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vesicular stomatitis virus |
| Cell Type | EPT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Vesicular stomatitis virus (CHEMBL613739) ↗| Type | ORGANISM |
| Organism | Vesicular stomatitis virus |
Publication
Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.14 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088346 | — | — | 1 | 5.39 |
| CHEMBL1098690 | — | — | 1 | 5.39 |
| CHEMBL1084906 | — | — | 1 | 5.33 |
| CHEMBL1098374 | — | — | 1 | 5.32 |
| CHEMBL1098691 | — | — | 1 | 5.25 |
| CHEMBL1092508 | — | — | 1 | 5.21 |
| CHEMBL1077006 | — | — | 1 | 5.18 |
| CHEMBL1084905 | — | — | 1 | 5.10 |
| CHEMBL1092507 | — | — | 1 | 5.02 |
| CHEMBL1098689 | — | — | 1 | 4.88 |
| CHEMBL539581 | TILORONE HYDROCHLORIDE | -1.0 | 1 | 4.87 |
| CHEMBL1088347 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088346 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL1098690 | — | IC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL1084906 | — | IC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL1098374 | — | IC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL1098691 | — | IC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL1092508 | — | IC50 | = | 6165.95 | nM | 5.21 |
| CHEMBL1077006 | — | IC50 | = | 6606.93 | nM | 5.18 |
| CHEMBL1084905 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL1092507 | — | IC50 | = | 9549.93 | nM | 5.02 |
| CHEMBL1098689 | — | IC50 | = | 13182.57 | nM | 4.88 |
| CHEMBL539581 | TILORONE HYDROCHLORIDE | IC50 | = | 13489.63 | nM | 4.87 |
| CHEMBL1088347 | — | IC50 | = | 19952.62 | nM | 4.70 |