Assay Detail
Binding
CHEMBL1102015
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Displacement of [125I]SRIF-14 from rat cortex membrane SST2 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.27 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076624 | — | — | 1 | 6.94 |
| CHEMBL1076623 | — | — | 1 | 6.82 |
| CHEMBL1076622 | — | — | 1 | 6.64 |
| CHEMBL1076625 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076624 | — | Kd | = | 114.82 | nM | 6.94 |
| CHEMBL1076623 | — | Kd | = | 151.36 | nM | 6.82 |
| CHEMBL1076622 | — | Kd | = | 229.09 | nM | 6.64 |
| CHEMBL1076625 | — | Kd | = | 20892.96 | nM | 4.68 |