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Assay Detail

CHEMBL1102037

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine heart sub-mitochondrial membrane SQR assessed as ubiquinol-dependent reduction of DCIP after 10 mins by spectrophotometry
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthetic atpenin analogs: Potent mitochondrial inhibitors of mammalian and fungal succinate-ubiquinone oxidoreductase.
Selby TP, Hughes KA, Rauh JJ, Hanna WS.
Bioorg Med Chem Lett (2010) 20 : 1665 -1668
PubMed 20137945 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 6.68 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1087378 1 8.52
CHEMBL1081615 ATPENIN A5 1 8.40
CHEMBL1087379 1 8.30
CHEMBL1081091 1 8.10
CHEMBL1080736 1 8.10
CHEMBL1088286 1 7.70
CHEMBL1076748 1 7.02
CHEMBL1080570 1 6.95
CHEMBL1087377 1 6.90
CHEMBL1088287 1 6.90
CHEMBL1076551 1 6.49
CHEMBL1086723 1 6.34
CHEMBL1086725 1 6.31
CHEMBL1081092 1 6.20
CHEMBL1088147 1 6.10
CHEMBL1081259 1 5.90
CHEMBL1076544 BOSCALID -1.0 1 5.75
CHEMBL1076731 1 5.47
CHEMBL1076713 1 5.18
CHEMBL1088148 1 4.89
CHEMBL1081273 1 4.86
CHEMBL1086724 1 -
CHEMBL1087498 1 -
CHEMBL1081106 1 -
CHEMBL1081274 1 -
CHEMBL1081614 1 -
CHEMBL1087371 1 -
CHEMBL1076712 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1087378 IC50 = 3.0 nM 8.52
CHEMBL1081615 ATPENIN A5 IC50 = 4.0 nM 8.40
CHEMBL1087379 IC50 = 5.0 nM 8.30
CHEMBL1081091 IC50 = 8.0 nM 8.10
CHEMBL1080736 IC50 = 8.0 nM 8.10
CHEMBL1088286 IC50 = 20.0 nM 7.70
CHEMBL1076748 IC50 = 96.0 nM 7.02
CHEMBL1080570 IC50 = 112.0 nM 6.95
CHEMBL1087377 IC50 = 125.0 nM 6.90
CHEMBL1088287 IC50 = 127.0 nM 6.90
CHEMBL1076551 IC50 = 326.0 nM 6.49
CHEMBL1086723 IC50 = 454.0 nM 6.34
CHEMBL1086725 IC50 = 492.0 nM 6.31
CHEMBL1081092 IC50 = 630.0 nM 6.20
CHEMBL1088147 IC50 = 795.0 nM 6.10
CHEMBL1081259 IC50 = 1270.0 nM 5.90
CHEMBL1076544 BOSCALID IC50 = 1790.0 nM 5.75
CHEMBL1076731 IC50 = 3400.0 nM 5.47
CHEMBL1076713 IC50 = 6560.0 nM 5.18
CHEMBL1088148 IC50 = 12800.0 nM 4.89
CHEMBL1081273 IC50 = 13800.0 nM 4.86
CHEMBL1086724 IC50 > 30000.0 nM -
CHEMBL1087498 IC50 > 30000.0 nM -
CHEMBL1081106 IC50 > 30000.0 nM -
CHEMBL1081274 IC50 > 30000.0 nM -
CHEMBL1081614 IC50 > 30000.0 nM -
CHEMBL1087371 IC50 > 30000.0 nM -
CHEMBL1076712 IC50 > 30000.0 nM -