Assay Detail
Binding
CHEMBL1102108
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Inhibition of PI3Kgamma
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.05 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086736 | — | — | 1 | 6.27 |
| CHEMBL1076721 | — | — | 1 | 6.00 |
| CHEMBL1080902 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086736 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL1076721 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1080902 | — | Ki | = | 1300.0 | nM | 5.89 |