Assay Detail
Binding
CHEMBL1103424
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Inhibition of MMP2 by fluorometric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.61 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090647 | — | — | 1 | 9.15 |
| CHEMBL1092104 | — | — | 1 | 8.82 |
| CHEMBL550148 | — | — | 1 | 8.70 |
| CHEMBL1089843 | — | — | 1 | 8.38 |
| CHEMBL561625 | — | — | 1 | 7.92 |
| CHEMBL181244 | — | — | 1 | 7.92 |
| CHEMBL311932 | — | — | 1 | 7.89 |
| CHEMBL1089842 | — | — | 1 | 7.77 |
| CHEMBL1088878 | — | — | 1 | 7.68 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.60 |
| CHEMBL1090284 | — | — | 1 | 7.54 |
| CHEMBL83508 | — | — | 1 | 7.50 |
| CHEMBL1090283 | — | — | 1 | 7.40 |
| CHEMBL1093690 | — | — | 1 | 6.72 |
| CHEMBL1090035 | — | — | 1 | 6.72 |
| CHEMBL1093689 | — | — | 1 | 6.41 |
| CHEMBL226439 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090647 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1092104 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL550148 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1089843 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL561625 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL181244 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL311932 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1089842 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1088878 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1090284 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL83508 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1090283 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1093690 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1090035 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1093689 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL226439 | — | IC50 | = | 5000.0 | nM | 5.30 |