Assay Detail
Binding
CHEMBL1103430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAM17 in human A2774 cells assessed as inhibition of constitutive sALCAM release by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.76 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089842 | — | — | 1 | 6.58 |
| CHEMBL1089843 | — | — | 1 | 5.96 |
| CHEMBL514138 | CGS-27023A | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089842 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1089843 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 18000.0 | nM | 4.75 |