Assay Detail
Binding
CHEMBL1103505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]histamine human recombinant histamine H4 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.57 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093180 | — | — | 1 | 7.72 |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | 7.57 |
| CHEMBL129199 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093180 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL260374 | THIOPERAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL129199 | — | Ki | = | 38.0 | nM | 7.42 |