Assay Detail
Functional
CHEMBL1103537
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Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.03 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092654 | — | — | 1 | 8.09 |
| CHEMBL1089225 | — | — | 1 | 7.99 |
| CHEMBL1093466 | — | — | 1 | 7.59 |
| CHEMBL1089224 | — | — | 1 | 7.30 |
| CHEMBL1089863 | — | — | 1 | 7.29 |
| CHEMBL150961 | — | — | 1 | 7.20 |
| CHEMBL1090529 | — | — | 1 | 7.14 |
| CHEMBL1089226 | — | — | 1 | 7.12 |
| CHEMBL1089548 | — | — | 1 | 7.06 |
| CHEMBL1092655 | — | — | 1 | 6.97 |
| CHEMBL1093467 | — | — | 1 | 6.73 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 6.58 |
| CHEMBL1089517 | — | — | 1 | 6.50 |
| CHEMBL210884 | — | — | 1 | 6.40 |
| CHEMBL1089220 | — | — | 1 | 6.33 |
| CHEMBL1089862 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092654 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL1089225 | — | EC50 | = | 10.3 | nM | 7.99 |
| CHEMBL1093466 | — | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL1089224 | — | EC50 | = | 50.1 | nM | 7.30 |
| CHEMBL1089863 | — | EC50 | = | 51.5 | nM | 7.29 |
| CHEMBL150961 | — | EC50 | = | 63.7 | nM | 7.20 |
| CHEMBL1090529 | — | EC50 | = | 72.9 | nM | 7.14 |
| CHEMBL1089226 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1089548 | — | EC50 | = | 87.5 | nM | 7.06 |
| CHEMBL1092655 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL1093467 | — | EC50 | = | 187.9 | nM | 6.73 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 260.1 | nM | 6.58 |
| CHEMBL1089517 | — | EC50 | = | 312.3 | nM | 6.50 |
| CHEMBL210884 | — | EC50 | = | 399.4 | nM | 6.40 |
| CHEMBL1089220 | — | EC50 | = | 466.8 | nM | 6.33 |
| CHEMBL1089862 | — | EC50 | = | 609.1 | nM | 6.21 |