Assay Detail
Binding
CHEMBL1103568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant LXRbeta ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.08 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 6.77 |
| CHEMBL1093499 | — | — | 1 | 6.07 |
| CHEMBL602446 | — | — | 1 | 5.77 |
| CHEMBL1089232 | — | — | 1 | 5.70 |
| CHEMBL1093532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1093499 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL602446 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1089232 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1093532 | — | EC50 | > | 1000.0 | nM | - |