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Assay Detail

CHEMBL1103699

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, cytotoxicity and DNA-binding of novel bisnaphthalimidopropyl derivatives in breast cancer MDA-MB-231 cells.
Barron GA, Bermano G, Gordon A, Kong Thoo Lin P.
Eur J Med Chem (2010) 45 : 1430 -1437
PubMed 20064676 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.34 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1098888 1 5.57
CHEMBL268909 BNIPDADEC 1 5.48
CHEMBL53463 DOXORUBICIN 4.0 1 5.44
CHEMBL1098885 BISNAPHTHALIMIDOPROPYL SPERMIDINE TRIHYDROBROMIDE 1 5.34
CHEMBL1098887 1 5.34
CHEMBL1098886 1 5.29
CHEMBL1098890 1 5.22
CHEMBL1098891 1 5.21
CHEMBL1098889 1 5.16
CHEMBL1098892 BISPHTHALIMIDOPROPYLDIAMINODECANE DIHYROBROMIDE 1 -
CHEMBL1095300 NAPHTHALIMIDOPROPYLAMINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1098888 IC50 = 2680.0 nM 5.57
CHEMBL268909 BNIPDADEC IC50 = 3320.0 nM 5.48
CHEMBL53463 DOXORUBICIN IC50 = 3610.0 nM 5.44
CHEMBL1098885 BISNAPHTHALIMIDOPROPYL SPERMIDINE TRIHYDROBROMIDE IC50 = 4590.0 nM 5.34
CHEMBL1098887 IC50 = 4540.0 nM 5.34
CHEMBL1098886 IC50 = 5120.0 nM 5.29
CHEMBL1098890 IC50 = 6060.0 nM 5.22
CHEMBL1098891 IC50 = 6150.0 nM 5.21
CHEMBL1098889 IC50 = 6880.0 nM 5.16
CHEMBL1098892 BISPHTHALIMIDOPROPYLDIAMINODECANE DIHYROBROMIDE IC50 > 40000.0 nM -
CHEMBL1095300 NAPHTHALIMIDOPROPYLAMINE IC50 > 40000.0 nM -