Assay Detail
Functional
CHEMBL1103711
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.21 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096881 | — | — | 1 | 6.57 |
| CHEMBL1096880 | — | — | 1 | 6.30 |
| CHEMBL1096876 | — | — | 1 | 6.26 |
| CHEMBL1096879 | — | — | 1 | 6.22 |
| CHEMBL1096567 | — | — | 1 | 6.21 |
| CHEMBL1096568 | — | — | 1 | 6.17 |
| CHEMBL1096877 | — | — | 1 | 6.11 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 6.10 |
| CHEMBL1096878 | — | — | 1 | 6.08 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096881 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1096880 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1096876 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1096879 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1096567 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1096568 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1096877 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1096878 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 830.0 | nM | 6.08 |