Assay Detail
Functional
CHEMBL1103714
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Antioxidant activity in Sprague-Dawley rat kidney assessed as lipid peroxidation by thiobarbituric acid assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.77 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096878 | — | — | 1 | 5.16 |
| CHEMBL1096877 | — | — | 1 | 4.92 |
| CHEMBL1096567 | — | — | 1 | 4.86 |
| CHEMBL1096879 | — | — | 1 | 4.84 |
| CHEMBL1096880 | — | — | 1 | 4.82 |
| CHEMBL1096568 | — | — | 1 | 4.80 |
| CHEMBL1096881 | — | — | 1 | 4.79 |
| CHEMBL1096876 | — | — | 1 | 4.69 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 4.64 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096878 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL1096877 | — | IC50 | = | 12080.0 | nM | 4.92 |
| CHEMBL1096567 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL1096879 | — | IC50 | = | 14560.0 | nM | 4.84 |
| CHEMBL1096880 | — | IC50 | = | 15050.0 | nM | 4.82 |
| CHEMBL1096568 | — | IC50 | = | 15780.0 | nM | 4.80 |
| CHEMBL1096881 | — | IC50 | = | 16270.0 | nM | 4.79 |
| CHEMBL1096876 | — | IC50 | = | 20330.0 | nM | 4.69 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 22990.0 | nM | 4.64 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 64630.0 | nM | 4.19 |