Assay Detail
Binding
CHEMBL1103716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aldose reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of aldose reductase inhibition and docking studies of 6'-nitro and 6',6''-dinitrorosmarinic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.97 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.60 |
| CHEMBL261703 | — | — | 1 | 6.13 |
| CHEMBL260778 | — | — | 1 | 5.74 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL261703 | — | IC50 | = | 741.0 | nM | 6.13 |
| CHEMBL260778 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | = | 3910.0 | nM | 5.41 |