Assay Detail
Binding
CHEMBL1103720
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Inhibition of PKA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.14 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096271 | — | — | 1 | 7.75 |
| CHEMBL1095621 | — | — | 1 | 7.50 |
| CHEMBL1095622 | — | — | 1 | 7.44 |
| CHEMBL1097972 | — | — | 1 | 7.39 |
| CHEMBL1094320 | — | — | 1 | 7.35 |
| CHEMBL1095612 | — | — | 1 | 7.27 |
| CHEMBL1097956 | — | — | 1 | 7.23 |
| CHEMBL1095278 | — | — | 1 | 7.18 |
| CHEMBL1098302 | — | — | 1 | 7.17 |
| CHEMBL1097602 | — | — | 1 | 7.11 |
| CHEMBL1095931 | — | — | 1 | 7.10 |
| CHEMBL1097955 | — | — | 1 | 7.07 |
| CHEMBL1094321 | — | — | 1 | 6.95 |
| CHEMBL1097604 | — | — | 1 | 6.92 |
| CHEMBL1095279 | — | — | 1 | 6.91 |
| CHEMBL1097973 | — | — | 1 | 6.86 |
| CHEMBL1095285 | — | — | 1 | 6.85 |
| CHEMBL1094637 | — | — | 1 | 6.42 |
| CHEMBL1095294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096271 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1095621 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1095622 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1097972 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1094320 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1095612 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1097956 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1095278 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1098302 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1097602 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1095931 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1097955 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1094321 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1097604 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1095279 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1097973 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL1095285 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL1094637 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL1095294 | — | IC50 | < | 31.0 | nM | - |