Assay Detail
Binding
CHEMBL1103722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p70S6K
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.90 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097972 | — | — | 1 | 7.72 |
| CHEMBL1095621 | — | — | 1 | 7.68 |
| CHEMBL1094320 | — | — | 1 | 7.14 |
| CHEMBL1096271 | — | — | 1 | 7.12 |
| CHEMBL1095612 | — | — | 1 | 7.11 |
| CHEMBL1095278 | — | — | 1 | 7.10 |
| CHEMBL1095294 | — | — | 1 | 7.06 |
| CHEMBL1095622 | — | — | 1 | 7.03 |
| CHEMBL1097955 | — | — | 1 | 7.01 |
| CHEMBL1097602 | — | — | 1 | 6.97 |
| CHEMBL1095931 | — | — | 1 | 6.97 |
| CHEMBL1098302 | — | — | 1 | 6.74 |
| CHEMBL1097956 | — | — | 1 | 6.67 |
| CHEMBL1094321 | — | — | 1 | 6.66 |
| CHEMBL1095279 | — | — | 1 | 6.63 |
| CHEMBL1097604 | — | — | 1 | 6.59 |
| CHEMBL1097973 | — | — | 1 | 6.46 |
| CHEMBL1094637 | — | — | 1 | 6.35 |
| CHEMBL1095285 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097972 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1095621 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1094320 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1096271 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1095612 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1095278 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1095294 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1095622 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1097955 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1097602 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL1095931 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1098302 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL1097956 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL1094321 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL1095279 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL1097604 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL1097973 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL1094637 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL1095285 | — | IC50 | = | 763.0 | nM | 6.12 |