Assay Detail
Binding
CHEMBL1103822
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Inhibition of CDK2/cyclin E
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.61 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1087073 | — | — | 1 | 8.77 |
| CHEMBL1087075 | — | — | 1 | 8.74 |
| CHEMBL1088704 | — | — | 1 | 8.72 |
| CHEMBL1086662 | — | — | 1 | 8.65 |
| CHEMBL1098686 | — | — | 1 | 8.28 |
| CHEMBL369303 | — | — | 1 | 8.13 |
| CHEMBL1087074 | — | — | 1 | 8.10 |
| CHEMBL1086683 | — | — | 1 | 8.08 |
| CHEMBL1086701 | — | — | 1 | 8.06 |
| CHEMBL1086950 | — | — | 1 | 8.00 |
| CHEMBL1099029 | — | — | 1 | 7.96 |
| CHEMBL1086811 | — | — | 1 | 7.63 |
| CHEMBL1086700 | — | — | 1 | 7.22 |
| CHEMBL1086951 | — | — | 1 | 7.12 |
| CHEMBL1087739 | — | — | 1 | 5.53 |
| CHEMBL1099039 | — | — | 1 | 5.38 |
| CHEMBL1087740 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1087073 | — | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL1087075 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL1088704 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL1086662 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL1098686 | — | IC50 | = | 5.27 | nM | 8.28 |
| CHEMBL369303 | — | IC50 | = | 7.35 | nM | 8.13 |
| CHEMBL1087074 | — | IC50 | = | 8.01 | nM | 8.10 |
| CHEMBL1086683 | — | IC50 | = | 8.32 | nM | 8.08 |
| CHEMBL1086701 | — | IC50 | = | 8.68 | nM | 8.06 |
| CHEMBL1086950 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL1099029 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL1086811 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL1086700 | — | IC50 | = | 60.3 | nM | 7.22 |
| CHEMBL1086951 | — | IC50 | = | 76.2 | nM | 7.12 |
| CHEMBL1087739 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL1099039 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL1087740 | — | IC50 | = | 8620.0 | nM | 5.06 |