Assay Detail
ADMET
CHEMBL1104130
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Cytotoxicity against human PBMC cells by XTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.21 | 4.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1075828 | — | — | 1 | 4.34 |
| CHEMBL1075825 | — | — | 1 | 4.26 |
| CHEMBL1075815 | — | — | 1 | 4.25 |
| CHEMBL1075829 | — | — | 1 | 4.17 |
| CHEMBL1075830 | — | — | 1 | 4.12 |
| CHEMBL1075821 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1075828 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1075825 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL1075815 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1075829 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL1075830 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL1075821 | — | IC50 | = | 80000.0 | nM | 4.10 |