Assay Detail
Functional
CHEMBL1104258
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Cytotoxicity against mouse L1210 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.44 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | — | 1 | 11.00 |
| CHEMBL1086649 | — | — | 1 | 8.27 |
| CHEMBL293412 | — | — | 1 | 8.22 |
| CHEMBL1087676 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL1086649 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL293412 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1087676 | — | IC50 | = | 550.0 | nM | 6.26 |