Assay Detail
Binding
CHEMBL1104417
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Displacement of [3H]5CT from 5HT7 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.17 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363452 | — | — | 1 | 9.70 |
| CHEMBL430706 | — | — | 1 | 9.17 |
| CHEMBL281923 | — | — | 1 | 8.96 |
| CHEMBL25815 | — | — | 1 | 8.67 |
| CHEMBL19215 | METERGOLINE | 2.0 | 1 | 8.20 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.40 |
| CHEMBL1091933 | — | — | 1 | 6.71 |
| CHEMBL1094908 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363452 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL430706 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL281923 | — | Ki | = | 1.096 | nM | 8.96 |
| CHEMBL25815 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL19215 | METERGOLINE | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL42 | CLOZAPINE | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1091933 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL1094908 | — | Ki | = | 265.0 | nM | 6.58 |